Erowid References Database
|
Marquardt GM, DiStefano V, Ling LL.
“Pharmacological and Toxicological Effects of B-3,4-Methylenedioxyamphetamine Isomers”.
Toxicol.Appl.Pharmacol.. 1978;45(3):675-83.
|
|
Abstract
The effects of §-3,4-methylenedioxyamphetamine (MDA) isomers on the behavior, toxic response and cardiovascular system of treated animals were reported. Methods Swiss-Webster mice (male, 18-22 g) were pretreated with SKF 525-A (10 mg/kg i.p.) 30 min before drug treatment and mortality was recorded after 4 hr. The behavioral effects on mice of (+/-)-MDA (40 mg/kg i.p.) (S)-MDA (20 mg/kg i.p.) and (R)-MDA (40 mg/kg i.p.) were compared with (R)-amphetamine (30 mg/kg), LSD (4 mg/kg), mescaline (40 mg/kg) or saline (5mcl/g i.p.). Mongrel cats (21, 2-4 kg) were anesthetized with sodium pentobarbital (30 mg/kg i.p.) and the effect of drugs administered i.v. on blood pressure, heart rate and respiration were recorded. Results (R'-MDA was the most potent isomer in hallucinogenic activity whereas (S)-MDA was the most potent in producing amphetamine-like behavior. The LD50 of (+/-)-MDA, (S)-MDA and (R)-MDA were 63, 34 and 87 mg/;kg respectively. SKY 525-A protected mice from the toxic effects of (+/-)- and (S)-MDA, but the toxic effects of (R)-MDA were potentiated. It was thought that a toxic metabolite, probably (S)-a-MDA produced) some of the toxic effects of (S)- and (+/-)-MDA. Many of the mice surviving tonic convulsions died next morning; thought to be analogous to fatigue and decreased motor activity seen in MDA intoxication in humans. All 3 isomers caused presser responses with tachyphylaxis, the response being blocked by phenoxybenzamine (5.0 mg/kg) or reserpine (5 mg/kg) pretreatment. They all potentiated the pressor response of norepinephrine (0.75mcg/kg) suggesting they were functioning as indirectly acting sympathomimetics. Repeated doses of (+/-)- and (R)-MDA caused a depressor response, which was found to occur with (R)-a-methyldopamine (1.5 mcg/kg), an assumed metabolite. (+/-)-, (S)- and (R)-MDA (100 mcg/kg) decreased the-heart-rate but this effect was blocked by atropine (AD mg/kg i.v.), which suggests that it was a reflex action
|
| # |
| Submit Comment |
|
[
Cite HTML ]
