Erowid References Database
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Perrson SA.
“The Effects of LSD and 2-Bromo LSD (BOL) on the Striatal Tyrosine Hydroxylation in Vivo”.
Acta Physiol.Scand.. 1976;? (Suppl. 440):103.
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Abstract
LSD may have an important influence on dopaminergic neurotransmission. The Authors earlier demonstrated increased brain DOPA levels after LSD and BOL in decarboxylase inhibited rats (Hollunger and Persson, Eur. J.Pharmacol. 1975, 31, 156). They have now found that LSD and BOL (0.125-0.5 mg/kg i.p.) increased the striatal DOPA accumulation after central de carboxylase inhibition. Increasing the dose of LSD (0.5-4 mg/kg i.p.) did not further increase DOPA level. BOL (2-4 mg/kg i.p.) however, similar to the dopamine (DA) receptor antagonist haloperidol gave a maximal DOPA accumulation. LSD (0.5 mg/kg i.p.), similar to the DA receptor agonist apomorphine, inhibited the increased DOPA levels observed after interruption of the impulse flow in the nigrostriatal pathways by cerebral hemisection or by gamma-butyrolactone treatment. BOL did not affect these increased DOPA levels. LSD also diminished the increased DOPA accumulation 24 hr after reserpine (5 mg/kg -P ) Conclusions LSD may have both agonistic and antagonistic properties at central DA receptors, while BOL may only have antagonistic properties at these receptors.
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