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Pieri M, Sehaffner R, Pieri L, Da Prada M, Haefely W.
“Turning in MFB-Lesioned Rats and Antagonism of Neuroleptic Induced Catalepsy after Lisuride and LSD”.
Life Sci.. 1978;22(18):1615-22.
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Abstract
The effects of lisuride (Spofa), LSD (Sandoz) and apomorphine (Siegfried) were studied in rats with unilateral chemical lesion in the medial forebrain bundle (MFB). Methods Right MFB-lesion was induced in female SPF Fuellinsdorf albino rats by local injections of 3.5 mcg 6-hydroxydopamine (6-OHDA) or 10 mcg 5,6-dihydroxytryptamine (5,6-DHT) (both Regis) . Results LSD 200 mcg/kg i.p. and apomorphine 1 mg/kg i.p. induced contralateral turning in lesioned rats lasting 1 hr. whereas the turning elicited by 50 mcg/kg lisuride lasted more than 4 hr. Also lisuride was more effective in 6-OHDA-treated rats than in 5,6-DHT-lesioned rats. Pretreatment of the rats by 30 min with 1 mg/kg haloperidol i.p. (Janssen) antagonized both lisuride and LSD-induced turning. LSD and lisuride antagonized the catalepsy induced by 15 mg/kg i.p. prochloroperazine methanesulfonate (Roche) in intact male rats, in a dose dependent fashion. Maximum antagonism was seen 30 min after drug treatment; the LSD effect lasted 1 hr. lisuride was active for at least 3 hr. Conclusion These results in conjunction with biochemical data indicate that lisuride is a very potent agonist at central dopaminergic receptors
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