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Pijnenburg AJJ, Honig WMM, Struyker Boudier HAJ, Cools AR, van der Heyden JAM, van Rossum JM.
“Further Investigations on the Effects of Ergometrine and Other Ergot Derivatives Following Injection into the Nucleus Accumbens of the Rat”.
Arch.Intern.Pharmacodyn.. 1976;222(1):103-15.
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Abstract
The effects of injection of ergometrine (E) and other ergot derivatives into the nucleus accumbens on locomotor activity were studied. Methods Rats (200 + 20 g) were implanted with cannulae into the nucleus accumbens. Intracerebral injections of the drugs were given bilaterally. Locomotor activity was recorded continuously before and for at least 5 hr after the intracerebral injection. Results Bilateral injection of E (1 mcg) into the nucleus accumbens markedly stimulated locomotor activity. Propranolol, phenoxybenzamine, and methysergide (all 5 mg/kg i.p.) had no clear influence on the effect of E. Peripheral injection of E (2 mg/kg i,p.) immediately after intracerebral injection of E resulted in the sudden death of 8/9 rats. Scopolamine (1 and 15 mg/kg i.p.) produced and initial enhancement of the effect of E on locomotor activity, Pretreatment with reserpine (Serpasil, 2 mg/kg i,p.) alone or in combination with a-methyl-p-tyrosine methylester (100 mg/kg i.p.) potentiated the effect of E and reduced the time of latency of the E effect. Locomotor stimulation was reduced when L-dopa (50 mg/kg i.p.) and Ro-4-4602 (50 mg/kg i.p.) were administered prior to E, but not after pretreatment with 5-hydroxytryptophan (50 mg/kg i.p.) and Ro-4-4602. Apomorphine (2 mg/kg i.p.) administered about 10 min after onset of E-induced locomotor stimulation produced within 5-10 min stereotyped behavior lasting about 1 hr. Bilateral injection into the nucleus accumbens of haloperidol (Serenase, 2.5 ug) or (3,4-dibydroxyphenylamino)-2-imidazoline (DPI) (5mcg markedly inhibited the effect of E. Clonidine (5 1lg bilaterally) reduced the effect of E only slightly. Injection into the nucleus accumbens of DPI alone or of ergocornine, bromocyrptine (both Sandoz, 5 and 10 mcg), LSD dibydroergotamine (Sandoz), and methysergide (all 2 and 5 mcg) did not produce a clear locomotor stimulation.
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