Erowid References Database
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Rosecrans JA, Chance WT, Spencer RM.
“The Discriminative Stimulus Properties of Cyclazocine: Generalization Studies Involving Nalorphine, Morphine and LSD”.
Res.Commun.Chem.Pathol.Pharmacol.. 1978;20(2):221-37.
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Abstract
The discriminative stimulus(DS) properties of cyclazacine (C Z) were studied. Methods 6 Adult male rats were trained to the 2-lever-operant (FR-4) procedure with the correct lever randomized among sessions. Reinforcement was given on different levers when tests were performed 30 min after i.p. CZ or saline. Tests of generalization were conducted using various doses of LSD, morphine (MP), pentazocine (PZ) and nalorphine (NP). In 10 sessions, rats learned to discriminate between 2 mg/ kg CZ and saline, with 70-83% responses on 'correct' bar compared to 12-200n the same bar with saline. DS lasted at least 120 min after injection, tolerance did not develop over 10 mth, and response rates were unaltered. Rats trained to distinguish CZ could not discriminate between LSD (6.3-500 mcg), PZ (10 and 20 mg/kg), or MP (0.83-7.50 mg/kg) and saline. Response rates decreased with increase in drug dose, and in no case was response > 500n the CZ bar. MP, (0.83-7.50 mg/kg) given 30 min before CZ, did not affect the CZ response, but the lowest dose slightly increased the response rate (12.314.6 to 28.2 +7.6). Stimulus generalization was apparent following NP, but 10 times more NP was administered to produce a CZ response. Rats did not respond to 70 and 80 mg/kg NP. Naloxone given 15 min after the training dose of C Z. reduced both discriminative ability and response rates. A significant reduction was seen with 32 mg/kg and total inhibition at 48-58 mg/kg. Conclusion CZ acts at different CNS sites from those affected by MP, PZ and LSD.
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