Erowid References Database
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Roszell DK, Horita A.
“The effects of haloperidol and thioridazine on apomorphine- and LSD- induced hyperthermia in the rabbit”.
Journal of Psychiatric Research. 1975;12(2):117-123.
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Abstract
The administration of LSD (100 micrograms/kg) or apomorphine (4mg/kg) to male New Zealand rabbits resulted in a pronounced hyperthermic response accompanied by behavioral excitation and sympathetic activity. In addition, apomorphine exhibited several compulsive stereotyped responses, such as head turning and gnawing. Rabbits, which were pretreated with various doses of thioridazine or haloperidol, responded to LSD with slightly attenuated hyperthermia and behavioral ex citation. The apomorphine induced responses were markedly attenuated or abolished with far smaller doses of the neuroleptics. The hyperthermic action of apomorphine was more sensitive to the actions of the antagonists than were the behavioral signs, total blockade being seen with 0.50mg/kg of thioridazine and 0.05mg/kg of haloperidol. The hyperthermic response to apomorphine thus represents a sensitive dopaminergic response, and may serve as a useful model in the evaluation of the antidopamine activity of the neuroleptic drugs. 15 references. (Author abstract)
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| Notes # : (Nur Abstract aus: Psychopharmacology Abstracts vol. 14, no. 1, p. 46 (1976) vorhanden) |
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