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Stewart RM, Growdon JH, Cancian D, Baldessarini RJ.
“Myoclonus After 5 Hydroxytryptophan In Rats With Lesions Of Indoleamine Neurons In The Central Nervous System”.
Neurology. 1976;26(7):690-692.
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Abstract
A MYOCLONIC SYNDROME CONSISTING OF TREMOR MYOCLONUS, AND SEIZURES WAS PRODUCED FOLLOWING THE SYSTEMIC ADMINISTRATION OF HYDROXYTRYPTOPHAN TO ADULT RATS PREVIOUSLY GIVEN INTRACISTERNAL INJECTIONS OF 5 DIHYDROXYTRYPTAMINE AND SYSTEMIC DESMETHYLIMIPRAMINE, BUT NOT IN THEIR CONTROLS. THIS BEHAVIORAL RESPONSE--AS-BLOCKED BY PRETREATMENT WITH THE PUTATIVE SEROTONIN RECEPTOR BLOCKING AGENTS METHYSERGIDE, LYSERGIC ACID DIETHYLAMIDE AND BROMOLYSERGIC ACID DIETHYLAMIDE AS WELL AS CENTRALLY EFFECTIVE DOSES OF THE AROMATIC AMINO ACID DECARBOXYLASE INHIBITOR R04 4602. BLOCKERS OF RECEPTORS OF-OTHER NEUROTRANSMITTERS HAD LITTLE EFFECT. THIS NEUROLOGIC RESPONSE IN THE ADULT RAT MAY BE RELEVANT 'TO SOME FORMS OF CLINICAL MYOCLONUS AND MAY BE USEFUL IN TESTING POTENTIAL AGONISTS AND ANTAGONISTS OF SEROTONIN RECEPTORS IN THE MAMMALIAN CENTRAL NERVOUS SYSTEM.
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| Notes # : (Nur Zitat und Zusammenfassung aus Excerpta Medica Datenbank) |
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