Erowid References Database
|
Trulson ME, Stark AD, Jacobs BL.
“Comparative Effects Of Hallucinogenic Drugs In Rats With Unilateral 6-hydroxydopamine Lesions”.
Eur.J. Pharmacal. 1977;44:113-119.
|
|
Abstract
The dopaminergic actions of various hallucinogenic drugs were assesed by examining their effects on turning behavior in rats with unilateral 6-hydroxydopamine lesions of the nigro-striatal pahtway. LSD (0.1 and 0.2 mg/kg) produced strong contralateral turning, indicating that it is a potent dopamine receptor agonist, while BOL (5 mg/kg), a non-hallucinogenic congener of LSD, was found to be a weak dopamine receptor agonist. STP (2 and 5 mg/kg) and mescaline (50 and 100 mg/kg) produced significant ipsilateral turning, indicating that these compounds have a moderate dopamine-releasing action. DMT (10 and 20 mg/kg) and 5-M-DMT (0.75 and 1.25 mg/kg) produced weak ipsilateral turning, which was not signigicantly different from that produced by the non-hallucinogenic compounds tryptamine (40 mg/kg) or scopolamine (0.25 mg/kg). Psilocin (1-20 mg/kg) produced no significant turning in either direction. These data, in conjunction with previous studies, indicate that while inactivation of the brain serotonin system may be a necessary and sufficient condition for hallucinogenesis, the ability to activate dopamine receptors may be an important factor in determining the potency of hallucinogens.
|
| # |
| Submit Comment |
|
[
Cite HTML ]
