Erowid References Database
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Whitaker PM, Seeman P.
“High-Affinity 3H-Serotonin Binding to Caudate: Inhibition by Hallucinogens and Serotoninergic Drugs”.
Psychopharmacology. 1978;59:1 - 5.
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Abstract
The specific binding of 3H-serotonin to calf caudate homogenate was studied. The dissociation constant was 2 nM and the number of specific sites was 14 fmoles/mg protein. Of many drugs tested, inhibition of specific 3H-serotonin binding occurred almost exclusively with serotonin agonists and antagonists. The concentrations for 50 0nhibition of 3H-serotonin binding by serotonergic agonists follow: bufotenin, 6nM; 5-methoxytryptamine, 12nM; psilocin, 35nM; dimethyltryptamine, 220 nM; and tryptamine, 270 nM. The concentrations for the antagonists were: LSD 9.5nM; methysergide 16nM and metergoline 25nM.
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