Erowid References Database
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Arnt J, Scheel-Krüger J.
“GABAergic and Glycinergic Mechanisms Within the Substantia Nigra: Pharmacological Specificity of Dopamine-Independent Contralateral Turning Behavior and Interactions With Other Neurotransmitters”.
Psychopharmacology. 1979;62:267-277.
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Abstract
The pharmacological specificity of the GABA agonist muscimol-induced contralateral lurning behavior alter unilateral injection into substantia nigra pars reticulate (SNR) has been studied. Muscimol- “induced turning was antagonized by intranigral bicuculline methochloride (BMC) and picrotoxin, whereas antagonists of glycine, morphine, dopamine, noradrenaline, and serotonin were ineffective. Glycine induced a qualitatively similar turning behavior which was strychnine-sensitive but relatively BMC and picrotoxin- insensitive. Other drugs, including substance P. kainic I acid, clonidine, oxymetazoline, serotonin, and carbachol, induced turning that could be dissociated from the effect of muscimol. Muscimol-induced turning was dopamine-independent, indicated by resistance to haloperidol (1 mg/kg), to pretreatment with reserpine (7.5 mg/kg) plus a-methyl-p-tyrosine (200 mg/kg), to haloperidol injections into the SNR, striatum and nucleus accumbens, and finally to kainic acid lesions of the striatum. 6-Hydroxydopamine lesions increased the efficacy of intranigral muscimol, while kainic acid Álesions ot the SNR antagonized muscimol. Muscimol-induced turning was inhibited by oxotremorine i (0.25 mg/kp), by intranigral carbachol, and by apomorphine (0. tĐ0.5 mg/kg), but only moderately by intranigrally injected apomorphine. These data suggest specificity of GABA-agorist-induced contralateral turning and indicate an interaction between nigral GABA and other neurotransmitters, particularly dopamine and acetylcholine.
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