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Carr DM.
“Cytological and Cytogenetical Effect of Hallucinogenic Drugs on Virally Induced Murine Erythroleukemia”.
Dissertation Abstr.Intern.B. 1978;38,(12, Part I):5705.
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Abstract
The in vivo effects of hallucinogenic drugs (LSD and mescaline) on the mitotic and meiotic chromosomes of normal and virally induced erythroleukemic (RLV-A disease) BALB/c mice was studied. LSD-25 and mescaline p.o. independently worsened the disease when fed to preleukemic (RLV-A) BALB/c mice. The smallest LSD dose (0.5 mcg/kg) and mescaline dose (2.5 mg/kg) were the most effective whereas the largest doses were the least effective. Pretreatment with the hallucinogens did not disturb the normal progression of the disease. The animals became pre leukemic at 2-3 mths after inoculation with viremic plasma and manifested hepatosplenomegaly and terminal anemia. At midstage, the larger doses of LSD (1.0, 2.0 mcg/kg) and mescaline (5.0 mg/kg) resulted in a high 0f mortality by day-21. In terminal mice, all 3 dosages of both hallucinogens were toxic. Centrilobular lipid accumulation was observed in livers of normal BALB/c mice treated with 1.0 )lg/kg LSD for 5 wk. or 2.0 mcg/kg/wk for up to 5 wk. Mitotic chromosomal aberrations including aneuploids, polyploids, chromatic breaks, achromaticlesions, metacentrics and "chromocenters" were observed at a significant level when §ALB/c mice were fed p.o. with LSD. Spontaneous occurrences of metacentric chromosomes formed by two acrocentric/telocen tric chromosomes and "Chromocenters" were observed for the first time in somatic cells and in normal BALB/c mice. The observation of increased aneuploids, X-Y univalents and autosomal univalents in meiotic preparations were significant when compared to control values. There was a tendency for increased "chromocenters" in early prophase I of meiosis in LSD-treated mice. Very few m“totic and meiotic figures were observed when normal BALB/c mice were treated with mescaline. In RLV-A treated BALB/c mice, achromatic lesions and chromatic breaks increased with the progression of the disease. Increased aneuploids in the preleukemic state, aneuploids and chromatic breaks in the midstage were statistically significant. Loop-like configurations were observed in the pachytene stages of the preleukemic mice. Very few mitotic and meiotic figures were observed in both LSD and mescaline pretreated and post treated RLV -
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