Erowid References Database
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Haigler HJ, Spring DD.
“Drugs that Antagonize Limb Flick Behavior Induced by D-Lysergic Acid Diethylamide (LSD) in Cats”.
Psychopharmacology. 1979;64:31 - 34.
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Abstract
In cats observed in their home cages limb flicks (LF) are a sensitive measure of the behavioral affects of LSD. LF induced by LSD (50 mcg/kg) were clocked by dextrorphan (0.6 mg/kg), dextromethorphan (06 mg/lmcg), and imipramine (5 mg/kg) at doses that did not produce ataxia or sleep. Levorphanol (0.6 mg/kg) a narcotic that is a congener of dextrorphan, did not block LF induced by LSD possibly because it produced an excitatory effect when given alone Pentobarbital at low doses (2 and 4 mg/kg) increased the number of LF induced by LSD but at a high dose (8 mg/kg) decreased LF induced by LSD either by producing ataxia, so the cats tended to remain immobile, or by producing sleep. Chlorpromazine (CPZ) at three doses (2, 4, and 8 mg/kg) attenuated the effects of LSD on LF, but did not block LF as completely as the above three blocking drugs, and produced ataxia and sleep.
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