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Crow TJ, Bourne R, Cross AJ, Ferrier IN, Owen F, Johnstone EC, Owens DGC, Whitaker PM.
“Neurotransmitter Enzymes And Receptors In Postmortem Brain In Schizophrenia”.
Progress in Neuro-Psychopharmacology. 1980;? (Suppl. 1).
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Abstract
The following neurohumoural hypotheses of schizophrenia have been tested with negative
FINDINGS: (i) noradrenaline neurone degeneration; (ii) MAO deficit; (iii) GAD or GABA deficit; (iv) serotonin deficiency; and (v) dopamine neurons overactivity. However, there is evidence for an increase in numbers of dopamine receptors assessed by 3H-spiroperidol binding in two-thirds of our sample. 3H-ADIN and 3-flupenthixol (less the domperidone displaceable component) binding were not increased, and this suggests that the change in the dopamine receptor in schizophrenia may be limited to one type, perhaps the DA2 receptor. In our series of brains there were no consistent changes in GABA, LSD, 5-HT, QNB, diazepam or naloxone binding. The changes in the dopamine receptor have been assessed in relation to past drug treatment, presence of extrapyramidal symptoms, including tardive dyakinesia and to the presence of positive and negative symptoms of schizophrenia. The findings suggest that the increase in spiroperidol binding sites is related to the disease process and may be associated with positive symptoms.
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| Notes # : 12th Congress of the Collegium Neuro-Pharmacologicum (CIMP), Göteborg (S), Jun 22-26, 1980. Pergamon Press, Oxford, New York, etc. 1980; p. 118. Abstr. No. 149. |
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