Erowid References Database
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Inoue T, Niwaguchi T.
“Enzymic formation of dehydrogenated and hydroxylated metabolites from lysergic acid diethylamide by rat liver microsomes”.
Xenobiotica. 1980;10(5):343-348.
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Abstract
1. The metabolism of Lysergic acid diethylamide (LSD) was studied using rat liver microsomes, and two minor metabolites were obtained in addition to Lysergic acid diethylamide and N6-desmethyl-lysergic acid diethylamide (nor-LSD) which were reported previously. 2. One of the metabolites was identified as Lysergic acid ethylvinylamide, apparently formed by dehydrogenation of a diethylamide group in the side chain at the 8-position, and the other as the phenol 13-hydroxy-LSD. 3. The formation of both Lysergic acid ethylamide and Lysergic acid ethylvinylamide was similarly induced by pretreatment of rats with either phenobarbitone sodium or 3 methylcholanthrene, while nor-LSD formation was induced only by phenobarbitone and that of 13-hydroxy-LSD only by methylcholanthrene.
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