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Morgenstern R, Strutz G, Gold R, Fink H.
“Zur Beziehung zwischen Neuroleptika-induzierter Hemmung von Spontan-Lokomotion (pD2) and LSD-potenzierter Apomorphin-Lokomotion (pA2) an der Ratte. Einfluss verschiedener Serotoninantagonisten auf die LSD-potenzierte Apomorphin-Lokomotion der Ratte.”.
Zbl.Pharm.Pharmakother.Laboratoriumsdiagn.. 1980;119(6):634.
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Abstract
Studies on neuroleptic-induced inhibition of spontaneous locomotion (pD2) and LSD-potentiated apomorphine-locomotion (pA2) in the rat are reported. Neuroleptics inhibit locomotor spontaneous activity in rats in the open-field test. Subeffective doses of the same neuroleptics are able to shift the dose-effect curve of the LSD (100 mcg/kg i.p.) potentiated apomorphine locomotion increase, and tn cause drug- and dose-dependent non-competitive reduction. A correlation can be demonstrated between pD2 and pA2 value. Cyproheptadine (100 mcg/kg and 200 mcg/kg) is able to antagonize the potentiating effect of LSD on apomorphine-induced locomotion increase in the rat. A qualitatively similar effect has also been demonstrated for danitracen (100 mcg/kg and 500 mcg/kg) and pizatifen (500 mcg/kg). The 2 agents did not influence locomotion in NaCl controls or the apomorphine effect.
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