Erowid.org: Erowid Reference 3596 : Electrophysiological Evidence For Presynaptic Inhibition Of Acetycholine Release By 5-hydroxytryptamine In The Enteric Nervous System : North RA, Henderson G, Katayama Y, Johnson SM

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North RA, Henderson G, Katayama Y, Johnson SM. “Electrophysiological Evidence For Presynaptic Inhibition Of Acetycholine Release By 5-hydroxytryptamine In The Enteric Nervous System”. Neuroscience. 1980;5:581-6. <a name="ref">North RA, Henderson G, Katayama Y, Johnson SM.</a> <a href="/references/3596">"Electrophysiological Evidence For Presynaptic Inhibition Of Acetycholine Release By 5-hydroxytryptamine In The Enteric Nervous System"</a> <i>Neuroscience</i>. 1980;5:581-6.
Text Abstract (this page) Full Text - English (749 K) Show Articles by North RA Henderson G Katayama Y Johnson SM Article IDs LSDID: 3398 Erowid RefID: 3596 PubMedID: unknown Collections Hofmann Collection MDMA Collection All References	Abstract Intracellular recordings were made in vitro from myenteric neurons of guinea pig ileum, 5-hydroxytryptamine was applied to the preparation either by superfusion or by iontophoresis on to the somatic membrane of the impaled cells. 5-Hydroxytryptamine (50 nM-2 mcM) depressed the amplitude of the cholinergic fast excitatory postsynaptic potential in every neuron to which it was applied (n = 58). 5-Hydroxytryptamine did not change the amplitude of depolarizations produced by iontophoretic application, off acetylcholine which were of a similar time course to the excitatory postsynaptic potential. Lysergic acid diethylamide (1 mcM) and methysergide (I-30 mcM) mimicked and sometimes blocked the action of 5-hydroxytryptamine. The results indicate that the inhibition of the peristaltic reflex by 5-hydroxytryptamine may be due to a blockade of transmission within the myenteric plexus brought about by a presynaptic action.
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