Erowid References Database
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Shannon HE.
“MDA and DOM: Substituted Amphetamines that do not Produce Amphetamine-Like Discriminative Stimuli in the Rat”.
Psychopharmacology. 1980;67:311-312.
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Abstract
3,4-Methylenedioxyamphetamine (MDA) I and 2,5-dimethoxy-4-methylamphetamine (DOM) are amphetamine congeners that produce both amphetamine-like and LSD-like effects. To evaluate whether MDA and DOM should be classed with amphetamine, their capacity to produce amphetamine like discriminative stimuli was assessed. Rats were trained to discriminate between saline and 1.0 mg/kg d-amphetamine in a two choice, discrete trial shock avoidance paradigm. Neither MDA nor DOM produced any amphetamine-appropriate responding when tested over a 30-fold dose range. The specificity of the procedure to detect amphetamine-like effects was demonstrated by the failure of LSD to produce any amphetamine appropriate responding. These results suggest that neither MDA nor DOM should be classed as amphetamine-like agents.
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