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Sovilla JY, Magistretti P, Schorderet M.
“Potentiation of Apomorphine-Induced Climbing Behaviour in Mice by d-LSD”.
Progr.Neuro-Psychopharmacol.. 1979;3(5-6):503-1l.
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Abstract
The effect of d-LSD on apomorphine-induced climbing behavior was studied in mice. Male ICR2 mice (25-40 g) were placed in cylindrical cages after i.p. injection of Ringer with or without drugs. After 30 min d-LSD (Sandoz) 0.1-2.5 mg/kg was injected. Inhibition of climbing behavior by d-LSD was dose dependent and maximal 15 min after drug administration and remained so for 30-50 min. d-LSD treated mice showed a significant potentiation of apomorphine (Siegfried, 5 mg/kg) induced climbing behavior with a maximal effect at 1 mg/kg. Similar doses of d-LSD alone induced no climbing behavior. 0.5 mg/kg i.p. haloperidol (Cilag) did not increase the scores due to apomorphine. Other mice received 200 mg/kg 5-hydroxytryptophan (Calbiochem) i.p. and were left for 20 min. followed by 2.5 mg/kg d-LSD or solvent. 10 Min later some also received 5 mg/kg apomorphine. Climbing behavior was observed 5 min after apomorphine injection. Mice given 5-hydroxytryptophan alone showed similar scores to those given d-LSD alone. 5-Hydroxytrytophan produced inhibition of apomorphine induced climbing behavior in contrast to d-LSD induced stimulation. d-LSD and 5-hydroxytryptophan treated mice also showed resting tremor, hyperreactivity and hypertonus. Conclusion d-LSD alone produces the typical serotoninergic syndrome, whereas in the presence of apomorphine a presynaptic interaction may modulate dopaminergic activity.
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