Erowid References Database
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Grome JJ, Harper AM.
“Local Cerebral Glucose Utilisation Following Indoleamine- and Piperazine-Containing 5-Hydroxytryptamine Agents”.
Journal of Neurochemistry. 1986;46:117-124.
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Abstract
Substances with varying structural components have been shown to have 5-hydroxytryptamine (5-HT)- like properties in the CNS. In this study, putative 5-HT agonists with indoleamine moeities--lysergic acid diethylamide (LSD) and 5-methoxy-N,N-dimethyltryptamine (5-MeODMT)--and with piperazine moeities--quipazine (Quip) and 6-chloro-2-( 1 -piperazinyl)pyrazine (6-CPP) were administered to rats. Local cerebral glucose utilisation was measured using the [14C]2-deoxmcglucose autoradiographic technique. It was found that in most cerebral structures, these substances produced dose-dependent reductions in glucose utilization. However, Quip and 6-CPP increased glucose utilization in specific areas of the diencephalon (e.g., nucleus reunions) and produced a biphasic effect in some but not all extrapyramidal structures (e.g., ventromedial caudate nucleus). No such increases inlocal cerebral glucose utilisation were measured following LSD or 5-MeODMT administration. These results indicate that although similarities exist between the effects of indoleamine- and piperazine- containing 5-HT agonists on local cerebral glucose utilisation there are also significant differences in the overall patterns of resopnse produced.
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