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Pazos A, Hoyer D, Palacios JM.
“The Binding Of Serotonergic Ligands To The Porcine Choroid Plexus: Characterization Of A New Type Of Serotonin Recognition Site”.
European Journal of Pharmacology. 1985;106(3):539-546.
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Abstract
The kinetic and pharmacological characterisitcs of the binding of [3H]5-HT (serotonin), [3H]8-OH-DPAT (8-OH-2-di-n-propylaminotetraline), [3H]LSD, [3H]ketanserin and [3H]mesulergine to membranes from frontal cortex, hippocampus and choroid plexus of pig brain were studied. The binding of these ligands to frontal cortex and hippocampus demonstrated the presence of 5-HT1 and 5-HT2 sites in both tissues, although hippocumpus was richer in 5-HT (subtype 5-HTA) sites. [3H]5-HT, [3H]mesulergine and [3H]LSD labeled the pig choroid plexus with high affinity. The pharmacological profiles of [3H]5-HT and [3H]mesulergine binding to this tissue were closely comparable. Ligands reported as selective for 5-HTA, 5HTB or 5-HT2 subtypes did not show high affinity for these binding sites. Therefore, these 5-HT binding sires in pig choroid plexus could be named 5-HT10. (other drugs with a high affinity for these sites were methysergide and mianserine. In pig frontal cortex, [3H]5-HT labeled the difterent subtypes of 5-HT sites. In contrast, [3H]mesulergine bound in pig frontal cortex to a small population of sites with pharmacological properties similar to those of the choroid plexus 5-HT10 sites. Possible physiological functions in which these sites might be involved are discussed.
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