Erowid References Database
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Ruffig DM, Domino EF.
“Effects of Selected Opioid Agonists and Antagonists on DMT- and LSD-25-Induced Disruption of Food-Rewarded Bar Pressing Behavior in the Rat”.
Psychopharmacology. 1981;75(3):226-230.
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Abstract
Several opioid agonists and antagonists interact with N,N-dimethyltryptamine (DMT) and lysergic acid diethylamide-25 (LSD) in adult male Holtzman rats trained on a positive reinforcement, fixed ratio 4 (FR4) behavioral schedule, i.e., a reward of 0.01 ml sugar-sweetened milk was earned on every fourth bar press. DMT (3.2 and 10.0 mg/kg) and LSD (0. l mg/kg) given IP with 0.9 % NaCI pretreatment, disrupted food-rewarded FR4 bar pressing. Animals were pretreated IP (10 - 15 min) with predetermined, behaviorally noneffective doses of morphine, methadone, naltrexone, and the (+)- and ( - )-enantiomers of naloxone prior to receiving DMT or LSD. Dose-dependent effects were shown with opioid agonist pretreatment. Morphine (0.32 - 1.0 mg/kg) and methadone (0.32 mg/kg) significantly antagonized the bar pressing disruption induced by DMT and LSD. Larger doses of morphine (3.2 mg/kg) and methadone (1.0 -3.2 mg/kg) potentiated only LSD-induced effects, with no effect on DMT-treated groups. The opioid antagonists ( - )- naloxone and naltrexone potentiated the disruption of bar pressing induced by DMT and LSD. Failure of (+)-naloxone to potentiate the DMT effects was attributed to a stereospecific opioid antagonist effect of ( - )-naloxone
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