Erowid.org: Erowid Reference 3711 : Pharmacological Evidence for the Existence of Multiple Functional Pools of Brain Serotonin: Analysis Of Brain Perfusate From Conscious Rats : Kleven MS, Dwoskin LP, Sparber SB

Erowid References Database

Kleven MS, Dwoskin LP, Sparber SB. “Pharmacological Evidence for the Existence of Multiple Functional Pools of Brain Serotonin: Analysis Of Brain Perfusate From Conscious Rats”. Journal of Neurochemistry. 1983;41(4). <a name="ref">Kleven MS, Dwoskin LP, Sparber SB.</a> <a href="/references/3711">"Pharmacological Evidence for the Existence of Multiple Functional Pools of Brain Serotonin: Analysis Of Brain Perfusate From Conscious Rats"</a> <i>Journal of Neurochemistry</i>. 1983;41(4).
Text Abstract (this page) Full Text - English (745 K) Show Articles by Kleven MS Dwoskin LP Sparber SB Article IDs LSDID: 3651 Erowid RefID: 3711 PubMedID: unknown Collections Hofmann Collection MDMA Collection All References	Abstract The serotonin reuptake inhibitor fluoxetine significantly reduced levels of endogenous 5-hydroxyindoleacetic acid (5-HIAA) in brain perfusate of rats implanted with push-pull cannulas. This occurred in conjunction with its suppressant effect upon fixed-ratio operant behavior. Behavior suppressed with the serotonin agonist lysergic acid diethylamide (LSD) occurred in conjunction-with a reduction of 5-HIAA only after 5- HIAA was elevated, shortly before, by 5 mg/kg of the serotonin precursor 5-hydroxytryptophan. Our data demonstrate the likely existence of multiple functional pools of serotonin in brain and support the notion that LSD preferentially affects a newly synthesized pool of this transmitter.
Comments and Responses to this Article #
Submit Comment

[ Cite HTML ]