Erowid References Database
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Ksir C, Slifer B.
“Drug Effects on Discrimination Performance at Two Levels of Stimulus Control”.
Psychopharmacology. 1982;76:286-290.
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Abstract
The effects of several doses of d-amphetamine, l, chlordiazepoxide (CDP), chlorpromazine (CPZ), LSD, pentobarbital, and scopolamine were examined in rats trained to respond to the brighter of two keys. On each of the 100 trials during a daily session, the rat pressed the key that was brighter (correct key) and received a food pellet, or pressed lit the incorrect key and terminated the trial without food, or pressed neither key for ins, allowing the trial to terminate. Within a session, trials were mixed randomly such that on 50 trials the incorrect key was not lit (easy trials) and on 50 trials the incorrect key was dimly lit (difficult trials). Amphetamine 1 (0.5 - 2.0mg/kg) reduced percent correct responses, with a greater effect on difficult than on easy trials CDP (4.0-16.0 mg/kg) and pentobarbital (2.0-16.0 mg/kg) reduced percent correct responses on the difficult trials at the highest doses tested. Scopolamine (0.12 - 1.0mg/kg) reduced both percent correct (more so on the difficult trials) and percent of trials on which a response was made, in a dose-related fashion. CPZ (1.0 - 4.0 mg/kg) reduced trial responding at 2.0 and 4.0mg/kg and reduced percent correct on the difficult 7 trials at 4.0 mg/kg. LSD (0.08 - 0.32mg/kg) did not signifcantly alter behavior in this study.
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