Erowid References Database
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Lucki I, Frazer A.
“Prevention of the Serotonin Syndrome in Rats by Repeated Administration of Monoamine Oxidase Inhibitors but not Tricyclic Antidepressants”.
Psychopharmacology. 1982;77:205 - 211.
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Abstract
The serotonin syndrome, a behavioral response produced by the activation of serotonin receptors, and 3H- serotonin binding were examined after repeated treatment of rats with different types of antidepressant-drugs. The serotonin syndrome was produced by the direct-acting serotonin receptor agonists 5-methoxy-N,N-dimethyltryptamine I (5-MeDMT) or d-lysergic acid diethylamide (LSD). Repeated, but not acute treatment of rats with monoamine oxidase inhibitors (nialamide, pargyline, and phenelzine) prevented the serotonin syndrome in response to either 5-MeDMT or LSD and also reduced 3H-serotonin binding in the brain stem and spinal cord. Pretreatment of rats with p-chlorophenylalanine blocked the ability of nialamide treatment to inhibit the serotonin syndrome caused by 5-MeDMT. By contrast, neither the serotonin syndrome or 3H-serotonin binding was affected significantly by the repeated administration of tricyclic antidepressants (amitriptyline, desmethylit mpramme, and chlorimipramine) or iprindole. Repeated monoamine oxidase inhibitor treatments may prevent the serotonin syndrome by causing a reduction of 3H-serotonin receptor binding sites in the brain stem and/or spinal cord.
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