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Marini JL, Jacobs BL, Sheard MH, Trulson ME.
“Activity of a Non-Hallucinogenic Ergoline Derivative, Lisuride, in an Animal Behavior Model for Hallucinogens”.
Psychopharmacology. 1981;73:328-331.
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Abstract
The behavioral effects of IP administration of lisuride, a non-hallucinogenic iso-lysergic acid amide analog structurally related to d-lysergic acid diethylamide (LSD), were examined in 15 cats. Ten animals were given saline or 6.25, l2.5, 25, 50, or 100 mcg/kg of lisuride and observed for 1 h by a rater blind to dose. There was a statistically significant effect of lisuride dose on the frequency of occurrence of the behaviors limb flicking, grooming, and abortive grooming, A time-course study with five cats at the most effective lisuride dose, 50 mcg/kg, revealed that the frequencies of occurrence of these behaviors reached a maximum during the first 2 h post l dose, and were comparable to frequencies after saline by 6 h post dose. An acute tolerance study with four cats scored for 90 min post dose revealed no significant tolerance to a 50 mcg/kg lisuride test dose administered 6, 24, or 72 h after an initial 50 mcg/kg dose. Acute cross tolerance studies with four cats scored for 90 min after an initial dose of 50 mcg/kg of LSD or of lisuride, followed 24 h later by 50 mcg/kg of lisuride or LSD, revealed no significant cross tolerance. The potency of lisuride relative to LSD was evaluated in six cats that were scored tor 60 min following 25 and 50 mcg/kg of LSD and of lisuride. On a molar basis, scores after lisuride were 5, 10 and 67 % those after LSD for limb flicking and grooming. These results indicate that lisuride, a non-hallucinogenic iso-lysergic acid derivative, is a false positive in the animal behavior model for hallucinogens.
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