Erowid References Database
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Mokler DJ, Commissaris RL, Henck JW, Rech RH.
“Naloxone Alters the Effects of LSD, DOM and Quipazine on Operant Behavior of Rats”.
Pharmacology Biochemistry and Behavior. 1984;21:333-337.
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Abstract
Administration of the indolealkylamine hallucinogen d-lysergic acid diethylamide (LSD), the phenethylamine hallucinogen 2,5-dimethoxy- 4-methylamphetamine (DOM) and the putative 5-hydroxytryptamine (5-HT) agonist quipazine all produced a dose dependent decrease in fixed ratio (FR-40) response rates and a concomitant increase in the number of Second pause intervals. Although nalaxone (4.0 mg/kg) had no effect on FR-40 responding per se, the pause-producing effects of LSD and, to a lesser extent, DOM were potentiated by pretreatment with naloxone. The action of quipazine on reinforcers was unaffected by combination with nalaxone, while the effect on pause intervals was slightly attenuated by nalaxone pretreatment. These data and previous studies suggest that the pause-producing effects of indolealkylamine and phenethylamine hallucinogens reflect their activation of a selective portion of brain 5-HT receptors. The potentiation of these effects by naloxone may relate to a modulation of central 5-HT systems by endogenous opioid mechanisms tending to restore an imbalance in various 5-HT pathways caused by the hallucinogenic 5-HT agonists. The more generalized disruptive effectss of quipazine on brain 5-HT systems may be less susceptible to the endogenous opioid modulation or may actually combine with it to induce a greater disruption.
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