Erowid.org: Erowid Reference 381 : Inhibitory metabolite complex formation of methylenedioxymethamphetamine with rat and human cytochrome P450. Particular involvement of CYP 2D : Delaforge M, Jaouen M, Bouille G

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Delaforge M, Jaouen M, Bouille G. “Inhibitory metabolite complex formation of methylenedioxymethamphetamine with rat and human cytochrome P450. Particular involvement of CYP 2D”. Environmental Toxicology and Pharmacology. 1999;7:153-8. <a name="ref">Delaforge M, Jaouen M, Bouille G.</a> <a href="/references/381">"Inhibitory metabolite complex formation of methylenedioxymethamphetamine with rat and human cytochrome P450. Particular involvement of CYP 2D"</a> <i>Environmental Toxicology and Pharmacology</i>. 1999;7:153-8.
Text Abstract (this page) Full Text - English (private) Show Articles by Delaforge M Jaouen M Bouille G Article IDs Erowid RefID: 381 PubMedID: unknown Collections Hofmann Collection MDMA Collection All References	Abstract Methylenedioxymethamphetamine (MDMA or ecstasy) is a common recreational drug used at rave parties. Unfortunately, MDMA may have neurological effects and in some cases causes hepatotoxicity. MDMA binds to cytochrome P450 in rat and human hepatic microsomal preparations. Upon metabolic transformation of either the methylenedioxy or the methylamino function, it forms an inhibitory P450-metabolite complex. This inhibitory complex is formed predominantly with the P450 2D isozymes. This complex formation may account for the clinical toxicity observed upon ingestion of MDMA, particularly with other compounds normally metabolized by P450 2D6.
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