Erowid References Database
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Bond HW, Guth PS.
“Interaction of 5-hydroxytryptamine and d-lysergic acid diethylamide in the transcallosal response”.
Life Science. 1968;7:249-258.
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Abstract
In an effort to study the effect of 5-hydroxytryptamine (5HT) and d-lysergic acid diethylamide (LSD) in the CNS, Marazzi and Hart (1,2) emplyed a modification of the method of Curtis and Bard (3) for transcallosally evoked cortical potentials. The former studies indicated that 5HT inhibited the transcallosal resopnse when injected intracarotidly. However, Koella dn co-workers (4,5) found that the observed effect of intracarotidly injected 5HT on potentials evoked by light flashes, is the algebraic sum of its effects at several sites, including carotid sinus, brain stem and cortiical receptors. In contrast, the experiments of Hart et al, (6) and Rodriguez et al (7) demonstrated that inhibition of transcallosally evoked potentials can be obtained independently of effects on subcortical neurons or on baro-or chemorecptors. Marrazzi and Hart (1.2) also showed that intracarotidly injected LSD inhibited the transcalosally evoked potential. The present invesigation differed from previous studies in that experiments were specifically designed to determine whether 5HT and LSD interact in the transcallosal preparation. Furthermore, the present experiments emplyed injection techniques designed to bypass baro- and chemorceptors. The construction of dose-transcallosal-inhibitory response curves for 5 HT and LSD was attempted as a means for studying the interaction of thse agents. Unfortunately, the dosage sequences of 5 HT caused the appearance of tachyphylaxis while dosage sequences of LSD often produced what appeared to be cortical spreading depression. Hence, meaningful quantitative interaction relationships could not be derived. The tachyphylaxis to 5 HT was nonetheless turned to good cause as will be seen. Evidence is presented which demonstrated that these compounds are mutually antagonistic.
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