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Dishotsky NI, Loughman WD, Mogar RE, Lipscomb WR.
“LSD and genetic damage. Is LSD chromosome damaging, carcinogenic, mutagenic, or teratogenic?”.
Science. 1971;172:431-440.
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Abstract
Chromosome damage in human white blood cells, leukemia, malformed infants, and animal mutations have been reported in man and other phytoorganisms that had been exposed to lysergic acid diethylamide (LSD). In the past 4.0 years, 68 studies and case reports directly related to this issue have been published. We have undertaken
to review these studies in order to clarify what is now known,
and to help resolve the problems re lating to the use of this drug. The questions we attempt to resolve are whether LSD is a chromosome-breaking agent and whether it is a carcinogen, a mutagen, or a teratogen in man.
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From our own work and from a review of the literature, we believe that
pure LSD ingested in moderate doses does not damage chromosomes in vivo,
does not cause detectable genetic damage, and is not a teratogen or a carcinogen in man. Within these bounds, therefore, we suggest that, other than during pregnancy, there is no present contraindication to the continued controlled experimental use of pure LSD.
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