Erowid.org: Erowid Reference 6012 : Enantio-selective cognitive and brain activation effects of N-ethyl-3,4-methylenedioxyamphetamine in humans : Spitzer M, Franke B, Walter H, Buechler J, Wunderlich AP, Schwab M, Kovar KA, Hermle L, Grön G

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Spitzer M, Franke B, Walter H, Buechler J, Wunderlich AP, Schwab M, Kovar KA, Hermle L, Grön G. “Enantio-selective cognitive and brain activation effects of N-ethyl-3,4-methylenedioxyamphetamine in humans”. Neuropharmacology. 2001 Aug 07;41(2):263-71. <a name="ref">Spitzer M, Franke B, Walter H, Buechler J, Wunderlich AP, Schwab M, Kovar KA, Hermle L, Grön G.</a> <a href="/references/6012">"Enantio-selective cognitive and brain activation effects of N-ethyl-3,4-methylenedioxyamphetamine in humans"</a> <i>Neuropharmacology</i>. 2001 Aug 07;41(2):263-71.
Text Abstract (this page) Full Text - English (private) Show Articles by Spitzer M Franke B Walter H Buechler J Wunderlich AP Schwab M Kovar KA Hermle L Grön G Article IDs Erowid RefID: 6012 PubMedID: 11489463 Collections Hofmann Collection MDMA Collection All References	Abstract In a randomised double-blind trial the subjective, neuropsychological and brain activation effects of the two enantiomers of the MDMA (ecstasy-) like drug N-ethyl-3,4-methylenedioxyamphetamine (MDE) were studied in five normal subjects using functional magnetic resonance imaging (fMRI). (S)-MDE produced elevated mood, impairments in conceptually driven cognition and marked right frontal activation. In contrast, (R)-MDE produced increased depression, enhanced visual feature processing, and activation of visual cortical and left frontal areas. Plasma concentrations were higher for the (R)-enantiomer. The so-called entactogenic effects of MDE are likely to be caused by the (S)-enantiomer, whereas (R)-MDE appears to be responsible for neurotoxic effects.
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