Erowid.org: Erowid Reference 680 : Blockade of the 3,4-methylenedioxymethamphetamine-induced changes in neurotensin and dynorphin A systems : Johnson M, Bush LG, Gibb JW, Hanson GR

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Johnson M, Bush LG, Gibb JW, Hanson GR. “Blockade of the 3,4-methylenedioxymethamphetamine-induced changes in neurotensin and dynorphin A systems”. Eur J Pharmacol. 1991;193(3):367-70. <a name="ref">Johnson M, Bush LG, Gibb JW, Hanson GR.</a> <a href="/references/680">"Blockade of the 3,4-methylenedioxymethamphetamine-induced changes in neurotensin and dynorphin A systems"</a> <i>Eur J Pharmacol</i>. 1991;193(3):367-70.
Text Abstract (this page) Full Text - English (private) Show Articles by Johnson M Bush LG Gibb JW Hanson GR Article IDs Erowid RefID: 680 PubMedID: unknown Collections Hofmann Collection MDMA Collection All References	Abstract The levels of neurotensin-like immunoreactivity (NTLI) and dynorphin-like immunoreactivity (DLI) in the neostriatum, nucleus cumbens and substantia nigra were increased 18 h after a single administration of MDMA (3,4-methylenedioxymethamphetamine, 10 mg/kg). Coadministration of SCH 23390, a dopamine D1 receptor antagonist, or MK-801, a non-competitive antagonist of the NMDA (N-methyl-D-aspartate) receptor complex, prevented the MDMA-induced increase of NTLI and DLI in all three brain structures while the administration of sulpiride, a dopamine D2 receptor antagonist, failed to alter the MDMA effects. These findings suggest that MDMA-induced changes in neurotensin and dynorphin involve both the dopaminergic and the glutamatergic systems.
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