Erowid References Database
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Geyer MA, Krebs K.
“Serotonin Receptor Involvement in an Animal Model of the Acute Effects of Hallucinogens”.
NIDA Research Monograph. 1994 Oct;146:124-161.
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Abstract
To facilitate the study of hallucinogenic drugs in the whole animal, investigators have explored a variety of animal behavioral measures that potentially could parallel hallucinogenic activity in humans (see Glennon, this volume), In the development of such models, d-lysergic acid diethylamide (LSD), the most well-known and potent of the hallucinogens, has been used most frequently as the prototype drug. Structurally an ergot alkaloid compound, LSD acts on the serotonin (5-hydroxytryptamine [5-HT]) system as a partial agonist at both 5-HT1A and 5-HT1C/2 receptors (Peroutka and Snyder 1979; Sanders-Bush et al. 1988). In attempting to model the behavioral effects of hallucinogens in humans, considerable research has focused on examining the responsiveness of animals to discrete phasic stimuli. Such studies have revealed that LSD reduces the rate of habituation of reflex responding (Geyer et al. 1978; Izquierdo 1975; Miliaressis and St. Laurent 1974) and produces alterations in both conditioned and unconditioned responding consistent with enhanced reactivity to irrelevant stimuli without direct alterations of sensory thresholds (Key 1964a,b; Key and Bradley 1960). Unfortunately, none of these effects has been demonstrated to be both common to a variety of hallucinogens and uncharacteristic of nonhallucinogens (Geyer et al. 1978; Stoff et al. 1978), criteria that are vital to an animal model of hallucinogenic activity.
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