Erowid.org: Erowid Reference 6925 : Exploratory hypoactivity induced by m-trifluoromethylphenylpiperazine (TFMPP) and m-chlorophenylpiperazine (m-CPP) : Klodzinska A, Jaros T, Chojnacka-Wojcik E, Maj J

Erowid References Database

Klodzinska A, Jaros T, Chojnacka-Wojcik E, Maj J. “Exploratory hypoactivity induced by m-trifluoromethylphenylpiperazine (TFMPP) and m-chlorophenylpiperazine (m-CPP)”. J Neural Transm Park Dis Dement Sect. 1989 Sep;1(3):207-18. <a name="ref">Klodzinska A, Jaros T, Chojnacka-Wojcik E, Maj J.</a> <a href="/references/6925">"Exploratory hypoactivity induced by m-trifluoromethylphenylpiperazine (TFMPP) and m-chlorophenylpiperazine (m-CPP)"</a> <i>J Neural Transm Park Dis Dement Sect</i>. 1989 Sep;1(3):207-18.
Text Abstract (this page) Full Text - English (private) Show Articles by Klodzinska A Jaros T Chojnacka-Wojcik E Maj J Article IDs Erowid RefID: 6925 PubMedID: 2775468 Collections Hofmann Collection MDMA Collection All References	Abstract The action of m-trifluoromethylphenylpiperazine (TFMPP) and m-chlorophenylpiperazine (m-CPP), inhibiting the exploratory activity (ambulation and peeping) of the rat was studied in the open field test. The effects of both these drugs were antagonized by mesulergine, metergoline and mianserin, and partly by methysergide. Spiperone showed an antagonistic action in one (mean) dose only. The effects of TFMPP and m-CPP were not antagonized by ipsapirone, gepirone, cyanopindolol, compound 21009, cyproheptadine, ritanserine, ICS 205930, idazoxan or atropine. The lesion produced by p-chloramphetamine attenuated the effects of TFMPP and abolished those of m-CPP. The obtained results permit an assumption that the TFMPP- and m-CPP-induced decrease in the exploratory activity is mediated probably by 5-HT1C receptors.
Comments and Responses to this Article #
Submit Comment

[ Cite HTML ]