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Kelly PA, Ritchie IM, Sangra M, Cursham MJA, Dickson EM, Kelly B, Neilson FP, Reidy MJ, Stevens MC.
“Hyperaemia in rat neocortex produced by acute exposure to methylenedioxymethamphetamine”.
Brain Res. 1994;665(2):315-8.
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Abstract
Cerebral blood flow and glucose utilization were measured in rat neocortex, hippocampus and striatum following methylenedioxymethamphetamine injection (5 mg/kg, i.v.), using the tracers [14C]iodoantipyrine and [14C]2-deoxyglucose, respectively. In control rats, blood flow was coupled to glucose metabolism, but in methylenedioxymethamphetamine-treated rats, marked hyperperfusion was measured in frontal and parietal cortex with no change in glucose use. This suggests that methylenedioxymethamphetamine has the potential to disrupt cerebrovascular control.
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