Erowid References Database
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Kramer K, Azmitia EC, Whitaker-Azmitia PM.
“In vitro release of [3H]5-hydroxytryptamine from fetal and maternal brain by drugs of abuse”.
Brain Res Dev Brain Res. 1994;78(1):142-6.
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Abstract
Cortical synaptosomes were prepared from pregnant dams (GD-17) and rat fetuses (ED-17), loaded with [3H]5-HT and assayed to evaluate release mediated by cocaine (COC), fenfluramine (FEN) and 3,4-methylenedioxymethamphetamine (MDMA). COC and FEN elicited a high-affinity (10(-9) M) release response in fetal tissue which was not apparent in the dam. MDMA-induced release was similar in magnitude in both tissue types. Consequently, the release of 5-HT from developing neurons may be one mechanism by which COC and FEN elicit their teratogenetic effects in utero.
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