Erowid.org: Erowid Reference 7242 : Failure of ibogaine to produce phencyclidine-like discriminative stimulus effects in rats and monkeys : Jones HE, Li H, Balster RL

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Jones HE, Li H, Balster RL. “Failure of ibogaine to produce phencyclidine-like discriminative stimulus effects in rats and monkeys”. Pharmacol Biochem Behav. 1998 Feb 31;59(2):413-8. <a name="ref">Jones HE, Li H, Balster RL.</a> <a href="/references/7242">"Failure of ibogaine to produce phencyclidine-like discriminative stimulus effects in rats and monkeys"</a> <i>Pharmacol Biochem Behav</i>. 1998 Feb 31;59(2):413-8.
Show Articles by Jones HE Li H Balster RL Article IDs Erowid RefID: 7242 PubMedID: 9476989 Collections Hofmann Collection MDMA Collection All References	Abstract The discriminative stimulus properties of ibogaine were investigated in rats trained to discriminate phencyclidine (PCP; 2.0 mg/kg, I.P.) from saline under a two-lever fixed-ratio (FR) 32 schedule of food reinforcement. Ibogaine (5.6-17.6 mg/kg, I.P.) showed a complete lack of substitution. Ibogaine (0.5-4.0 mg/kg, I.M.) also failed to generalize in rhesus monkeys trained to discriminate PCP (0.1 mg/kg, I.M.) from sham injection. Lysergic acid diethylamide (LSD), tested as a reference compound, produced partial substitution for PCP in rats and occasioned little responding on the PCP-associated lever in monkeys. These results demonstrate important differences between the behavioral effects of PCP and other types of hallucinogenic drugs such as LSD and ibogaine and do not support the hypothesis that the affinity of ibogaine for the PCP site on N-methyl-D-aspartate (NMDA) receptors plays a major role in its acute behavioral effects.
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