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Batista LM, de Almeida RN.
“Central Effects of the Constituents of Mimosa opthalmocentra Mart. ex Benth”.
Acta Farm. Bonaerense. 1997;16(2):83-6.
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Abstract
SUMMARY. A fraction containing the total alkaloids (FTA) of the plant Mimosa opthalmocenrra Mart. ex Benth. 50 and 100 mg/kg, i.p. and N.N,- Dimethyltryptamine (DMT), one of the compounds isolated, at 32, 64 and 128 mg/kg, i.p. produced the "5HT behavioral syndrome" in rats. Another substance isolated from the plant, hordenin, had no such effect. Pretreatment with ketanserin (10 mg/kg) inhibited all the behavioral syndrome elicited by FTA (100 mg/kg) and DMT (64 mg/k«) suggesting an action of the agents on 5HT2 receptors subtype in rat brain.
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