Erowid.org: Erowid Reference 7487 : Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells : Salazar M, Carracedo A, Salanueva IJ, Hernandez-Tiedra S, Lorente M, Egia A, Vazquez P, Blazquez C, Torres S, Garcia S, Nowak J, Fimia GM, Piacentini M, Cecconi F, Pandolfi PP, Gonzalez-Feria L, Iovanna JL, Guzman M, Boya P, Velasco G

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Salazar M, Carracedo A, Salanueva IJ, Hernandez-Tiedra S, Lorente M, Egia A, Vazquez P, Blazquez C, Torres S, Garcia S, Nowak J, Fimia GM, Piacentini M, Cecconi F, Pandolfi PP, Gonzalez-Feria L, Iovanna JL, Guzman M, Boya P, Velasco G. “Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells”. J Clin Invest. 2009 Apr 7;19(5). <a name="ref">Salazar M, Carracedo A, Salanueva IJ, Hernandez-Tiedra S, Lorente M, Egia A, Vazquez P, Blazquez C, Torres S, Garcia S, Nowak J, Fimia GM, Piacentini M, Cecconi F, Pandolfi PP, Gonzalez-Feria L, Iovanna JL, Guzman M, Boya P, Velasco G.</a> <a href="/references/7487">"Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells"</a> <i>J Clin Invest</i>. 2009 Apr 7;19(5).
Text Abstract (this page) External Text Show Articles by Salazar M Carracedo A Salanueva IJ Hernandez-Tiedra S Lorente M Egia A Vazquez P Blazquez C Torres S Garcia S Nowak J Fimia GM Piacentini M Cecconi F Pandolfi PP Gonzalez-Feria L Iovanna JL Guzman M Boya P Velasco G Article IDs Erowid RefID: 7487 PubMedID: 19349690 Collections Hofmann Collection MDMA Collection All References	Abstract Autophagy can promote cell survival or cell death, but the molecular basis underlying its dual role in cancer remains obscure. Here we demonstrate that Delta9-tetrahydrocannabinol (THC), the main active component of marijuana, induces human glioma cell death through stimulation of autophagy. Our data indicate that THC induced ceramide accumulation and eukaryotic translation initiation factor 2alpha (eIF2alpha) phosphorylation and thereby activated an ER stress response that promoted autophagy via tribbles homolog 3-dependent (TRB3-dependent) inhibition of the Akt/mammalian target of rapamycin complex 1 (mTORC1) axis. We also showed that autophagy is upstream of apoptosis in cannabinoid-induced human and mouse cancer cell death and that activation of this pathway was necessary for the antitumor action of cannabinoids in vivo. These findings describe a mechanism by which THC can promote the autophagic death of human and mouse cancer cells and provide evidence that cannabinoid administration may be an effective therapeutic strategy for targeting human cancers.
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