Erowid.org: Erowid Reference 767 : Major metabolites of (+/-)3,4-methylenedioxyamphetamine (MDA) do not mediate its toxic effects on brain serotonin neurons : McCann UD, Ricaurte GA

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McCann UD, Ricaurte GA. “Major metabolites of (+/-)3,4-methylenedioxyamphetamine (MDA) do not mediate its toxic effects on brain serotonin neurons”. Brain Res. 1991;545(1-2):279-82. <a name="ref">McCann UD, Ricaurte GA.</a> <a href="/references/767">"Major metabolites of (+/-)3,4-methylenedioxyamphetamine (MDA) do not mediate its toxic effects on brain serotonin neurons"</a> <i>Brain Res</i>. 1991;545(1-2):279-82.
Text Abstract (this page) Full Text - English (private) Show Articles by McCann UD Ricaurte GA Article IDs Erowid RefID: 767 PubMedID: unknown Collections Hofmann Collection MDMA Collection All References	Abstract The two major metabolites of (+/-)3,4-methylenedioxyamphetamine (MDA), alpha-methyldopamine (alpha-MeDA) and 3-O-methyl-alpha-methyldopamine (3-O-Me-alpha-MeDA), were administered to rats intracerebroventricularly and into brain parenchyma. In addition, their precursors, (alpha-MeDOPA and 3-O-Me-alpha-MeDOPA, respectively) were administered systemically, individually and in combination. None of these treatments produced a lasting depletion of brain serotonin (5-HT). These findings suggest that neither of MDA's major metabolites mediate its toxic effects on 5-HT neurons and that either a minor metabolite is responsible or that alternate mechanisms are involved.
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