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Rodriquez B, de la Torre MC, Jimeno M-L, Brune M, Vassallo N,Bondi ML, Piozzi F, Sevettaz O.
“Neoclerodane Diterpenoids from Scutellaria pontica”.
Journal of Natural Products. 1997 Nov 08;60(4):348-55.
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Abstract
Seven novel neoclerodane diterpenoids, scupontins A—G, have been isolated from the Me2CO extract of the aerial parts of Scutellaria pontica (1—7), together with the known neoclerodanes scutalbin A and scutalpin M. Structures 1-7 were established by exhaustive NMR spectroscopic studies and chemical transformations. Scupontins A—D (1—4, respectively) and scupontins E (5) and F (6) possess unusual [(3'S,3"S)-3'-{(3"-acetoxybutyryl)oxy]butyryloxy and [(3'S,3"S,3'"S)-3'[[3"[(3'"hydroxybutyryl)oxy]butyryl]oxy]butyryl]oxy substituents, respectively, attached to.the C-19 position of the neoclerodane framework. In the case of the 6a,7β-dibenzoate derivative 7 (scupontin G) its absolute configuration was established by the CD exciton chirality method.
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