Erowid References Database
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Aloi JA, Insel TR, Mueller EA, Murphy DL.
“Neuroendocrine and Behavioral Effects of m-Chlorophenylpiperazine Administration in Rhesus Monkeys”.
Life Sciences. 1984 Jan 20;34:1325-31.
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Abstract
The effects of m-chlorophenylpiperazine (mCPP), a serotonin receptor agonist, on the release of plasma prolactin (PRL), growth hormone (GH), and cortisol in the rhesus monkey were studied, mCPP was administered intravenously at doses of 0.5, 1.5, and 3.0 mg/kg. GH and cortisol were increased significantly at all doses while PRL was significantly increased only following administration of 3.0 mg/kg mCPP. mCPP administration also
produced behavioral alterations in each monkey, including sedation, penile erection, and defecation. PRL, GH and behavioral responses to mCPP were completely blocked by pretreatment with the serotonin antagonist metergoline (MTG). However, pretreatment
with MTG failed to entirely antagonize the cortisol response to mCPP. These data suggest that mCPP has prominent neuroendocrine and behavioral effects which are mediated, in
part, by serotonergic mechanisms.
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