Erowid References Database
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Arnt J, Hyttel J.
“Facilitation of 8-OHDPAT-induced forepaw treading of rats by the 5-HT2 agonist DOI”.
Eur J Pharmacol. 1989 Feb 12;161(1):45-51.
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Abstract
The potency of the serotonin 1A 5-HT1A agonist, 8-hydroxy-2-di-n-propylaminotetralin 8-OHDPAT, to induce forepaw treading was increased 20-fold after co-treatment with the 5-HT2 agonist, 1-2,5-dimethoxy-4-iodophenyl-2-aminopropane DOI. DOI induced head twitches which were inhibited by 8-OHDPAT. The putative 5-HT1B agonist, 1-3-trifluoromethylphenylpiperazine TFMPP, had a weak effect on the responses to DOI or 8-OHDPAT. The forepaw treading induced by 8-OHDPAT plus DOI was inhibited by high doses of --alprenolol, ketanserin or ritanserin, but was not influenced by the beta-adrenoceptor antagonist, ICI 118.551, or the 5-HT3 antagonist, ICS 205-930. A non-effective dose of --alprenolol increased the inhibitory effect of ketanserin and ritanserin. These results indicate a complex and different interaction between 5-HT1A and 5-HT2 receptors in the expression of two behavioural responses mediated by 5-HT.
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