Erowid References Database
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Barbeau A, Lescop J, Duplessis P, Elie R.
“Effect of 3,4-dimethoxyphenylethylamine injections upon dopamine metabolism in rats and dogs”.
Experientia. 1967 Jul 14;23(7):536-8.
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Abstract
Substances chemically related to dopamine 3-hydroxytyramine have been known to possess pharmacological effects. Such is the case for Mescaline 1 and 3, 4-dimethoxyphenylethylamine DIMPEA or D.M.P.E.2. The latter substance can produce in animals an akineto-rigid syndrome akin to the bradykinesia of Parkinson's disease
and to the catatonia of schizophrenia 2,3. Recently BARBEAU et al. 4 observed a selective increase in urinary dopamine excretion after an injection of DIMPEA to monkeys. In male albino Sprague-Dawley rats, a single injection of DIMPEA caused an increase in the concentration of dopamine in the central grey nuclei of the brain at the time of maximal clinical akinetic effect 5. This apparent interference of DIMPEA with dopamine metabolism may be of importance since a DIMPEA-Iike product has been isolated in the urine of parkinsonians 6-8 and since dopamine appears to be implicated in the etiology of bradykinesia in Parkinson's disease 9-11. The present paper intends to establish on a statistical basis, which was difficult with monkeys 4, the effect of DIMPEA injections upon dopamine metabolism and also to study this effect in other species.
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