Erowid.org: Erowid Reference 7880 : 5-Hydroxytryptamine depletion in mesencephalic nuclei of rat brain following a single injection of p-chloroamphetamine : Bertilsson L, Koslow SH, Costa E

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Bertilsson L, Koslow SH, Costa E. “5-Hydroxytryptamine depletion in mesencephalic nuclei of rat brain following a single injection of p-chloroamphetamine”. Brain Res. 1975 Jun 11;91(2):348-50. <a name="ref">Bertilsson L, Koslow SH, Costa E.</a> <a href="/references/7880">"5-Hydroxytryptamine depletion in mesencephalic nuclei of rat brain following a single injection of p-chloroamphetamine"</a> <i>Brain Res</i>. 1975 Jun 11;91(2):348-50.
Text Abstract (this page) Full Text - English (private) Show Articles by Bertilsson L Koslow SH Costa E Article IDs Erowid RefID: 7880 PubMedID: 1164685 Collections Hofmann Collection MDMA Collection All References	Abstract A single dose of p-chloroamphetamine PCA reduces the content of 5-hydroxytryptamine 5-HT and 5-hydroxyindoleacetic acid, the turnover rate of 5-HT and the activity of tryptophan-5-hydroxylase in rat brain for several months3,5,11,12. It has been suggested that this long lasting deficit is due to a neurotoxic effect, possibly mediated through a not yet identified epoxide or hydroxylamine metabolite of PCA5,12
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