Erowid.org: Erowid Reference 7988 : The 5-HT2 receptor agonist 1-2,5-dimethoxy-4-iodophenyl2-aminopropane increases brain tryptophan levels in the rat : Chaouloff F, Baudrie V, Layeillon C, Broqua P

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Chaouloff F, Baudrie V, Layeillon C, Broqua P. “The 5-HT2 receptor agonist 1-2,5-dimethoxy-4-iodophenyl2-aminopropane increases brain tryptophan levels in the rat”. Eur J Pharmacol. 1992 Apr 16;214(1):101-3. <a name="ref">Chaouloff F, Baudrie V, Layeillon C, Broqua P.</a> <a href="/references/7988">"The 5-HT2 receptor agonist 1-2,5-dimethoxy-4-iodophenyl2-aminopropane increases brain tryptophan levels in the rat"</a> <i>Eur J Pharmacol</i>. 1992 Apr 16;214(1):101-3.
Text Abstract (this page) Full Text - English (private) Show Articles by Chaouloff F Baudrie V Layeillon C Broqua P Article IDs Erowid RefID: 7988 PubMedID: 1533838 Collections Hofmann Collection MDMA Collection All References	Abstract Earlier studies have indicated that the sympathoadrenal system and the corticotropic axis control brain levels of tryptophan Trp, the precursor of 5-hydroxytryptamine 5-HT. We investigated the effects of 5-HT receptor agonists known to activate the sympathoadrenal system and/or the corticotropic axis on plasma and brain Trp levels. Neither the 5-HT1A receptor agonist 8-hydroxy-2-di-n-propylaminotetralin 8-OH-DPAT, 0.5 mg/kg s.c., nor the 5-HT1C receptor agonist 1-3-chlorophenylpiperazine mCPP, 2.5 mg/kg s.c. affected plasma and brain Trp levels. The 5-HT2 receptor agonist 1-2,5-dimethoxy-4-iodophenyl2-aminopropane DOI, 0.5-2 mg/kg s.c. increased brain Trp levels, an effect which was significant for the two highest doses used 1.5-2 mg/kg s.c..
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