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Dumont G, Van Hasselt J, de Kam M, van Gerven J, Touw D, Buitelaar J, Verkes R.
“Acute psychomotor, memory and subjective effects of MDMA and THC co-administration over time in healthy volunteers”.
J Psychopharmacol. 2010 Sep 6.
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Abstract
In Western societies a considerable percentage of young people expose themselves to the combination of 3,4-methylenedioxymethamphetamine MDMA or 'ecstasy' and cannabis. The aim of the present study was to assess the acute effects of co-administration of MDMA and THC the main psychoactive compound of cannabis on pharmacokinetics, psychomotor performance, memory and subjective experience over time. We performed a four-way, double blind, randomized, crossover, placebo-controlled study in 16 healthy volunteers 12 male, four female between the ages of 18 and 27. MDMA 100 mg was given orally, THC 4, 6, and 6 mg, interval of 90 min was vaporized and inhaled. THC induced more robust cognitive impairment compared with MDMA, and co-administration did not exacerbate single drug effects on cognitive function. However, co-administration of THC with MDMA increased desired subjective drug effects and drug strength compared with the MDMA condition, which may explain the widespread use of this combination.
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