Erowid References Database
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Aghajanian, G.K..
“Serotonin and the Action of LSD in the Brain”.
Psychiatric Annals. 1994 Mar;24(3):137-41.
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Abstract
In 1943, the chemist Albert Hoffman accidentally discovered the remarkably potent hallucinogenic properties of LSD d-lysergic acid diethylamide. Within the next decade, serotonin 5-hydroxytryptamine 5-HT, an endogenous indoleamine compound structurally related to LSD Figure 1, was found in various tissues of the body including the brain. Based on this structural similarity and the finding that LSD could antagonize
5-HT in peripheral tissues, it was proposed independently by Gaddum and Woolley that
the hallucinogenic effects of LSD might result from an antagonism of 5-HT in the brain. This hypothesis was soon expanded to include the possibility that LSD could mimic as well as antagonize the actions of 5-HT.1
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