Erowid References Database
Daly JW, Creveling CR, Witkop B.
“The chemorelease of norepinephrine from mouse hearts. Structure-activity relationships. I. Sympathomimetic and related amines”.
J Med Chem. 1966 May 02;9(3):273-80.
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Abstract
A rapid method for determining the chemorelease of cardiac norepinephrine in the mouse has been developed. Endogenous cardiac norepinephrine is prelabeled with 5 µcuriea of norepinephrine-7-H. The cardiac norepinephrine-H remaining in the heart after 3 hr averages 340 mµcuries. Lower levels of radioactivity are found in heart when animals are injected 1 hr after the norepinephrine-H with a compound that causes chemorelease.
The releasing potencies of a wide variety of sympathomimetic araines and related compounds have been determined. Structure-activity correlations are discussed.
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