Erowid References Database
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Dukat M, Young R, Glennon RA.
“Effect of PMA optical isomers and 4-MTA in PMMA-trained rats”.
Pharmacol Biochem Behav. 2002 May 19;72(1-2):299-305.
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Abstract
1-4-Methoxyphenyl-2-aminopropane PMA and its sulfur analog, 1-4-methylthiophenyl-2-aminopropane 4-MTA, have been misrepresented as the controlled substance analog, N-methyl-1-3,4-methylenedioxyphenyl-2-aminopropane MDMA 'Ecstasy'. Because MDMA has been shown to produce both amphetamine-like and N-methyl-1-4-methoxyphenyl-2-aminopropane PMMA-like stimulus effects in rats, we examined S+PMA, R-PMA and 4-MTA in rats trained to discriminate either PMMA 1.25 mg/kg or +amphetamine 1.0 mg/kg from saline vehicle. The sulfur analog of PMMA i.e., 4-MTMA was also examined. The PMMA stimulus generalized to R-PMA ED50-0.4 mg/kg, whereas S+PMA produced a maximum of 72 PMMA-appropriate responding. 4-MTA ED50-0.3 mg/kg also substituted for PMMA, but 4-MTMA produced a maximum of only 36 PMMA-appropriate responding. None of the four agents substituted for +amphetamine. Hence, like MDMA, R-PMA and 4-MTA are capable of producing PMMA stimulus effects in rats, but unlike MDMA, neither agent substituted for +amphetamine.
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