Erowid.org: Erowid Reference 8364 : Determination of the mechanism of demethylenation of (methylenedioxy)phenyl compounds by cytochrome P450 using deuterium isotope effects : Fukuto JM, Kumagai Y, Cho AK

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Fukuto JM, Kumagai Y, Cho AK. “Determination of the mechanism of demethylenation of (methylenedioxy)phenyl compounds by cytochrome P450 using deuterium isotope effects”. J Med Chem. 1991 Sep 22;34(9):2871-6. <a name="ref">Fukuto JM, Kumagai Y, Cho AK.</a> <a href="/references/8364">"Determination of the mechanism of demethylenation of (methylenedioxy)phenyl compounds by cytochrome P450 using deuterium isotope effects"</a> <i>J Med Chem</i>. 1991 Sep 22;34(9):2871-6.
Text Abstract (this page) Full Text - English (private) Show Articles by Fukuto JM Kumagai Y Cho AK Article IDs Erowid RefID: 8364 PubMedID: 1680196 Collections Hofmann Collection MDMA Collection All References	Abstract The mechanism of demethylenation of (methylenedioxy)benzene (MDB), (methylenedioxy)amphetamine (MDA), and (methylenedioxy)methamphetamine (MDMA) by purified rabbit liver cytochrome P450IIB4 has been investigated by using deuterium isotope effects. A comparison of the magnitude and direction of the observed kinetic isotope effects indicates that the three compounds are demethylenated by different mechanisms. The different mechanisms of demethylenation have been proposed on the basis of comparisons of the observed biochemical isotope effects with the isotope effects from purely chemical systems.
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